About MigraineMD

What is MigraineMD?

MigraineMD is the only all-in-one evidence-based natural migraine supplement that contains all the ingredients and doses recommended by national headache expert guidelines. MigraineMD is designed to be taken every night for at least 3 months to reduce headache frequency and severity.*

What makes MigraineMD unique?

Put simply: The right ingredients at the right dose.

MigraineMD is all-natural and 100% backed by science, containing only evidence-based ingredients at evidence-based doses. 

Many other combination natural supplements marketed for migraine contain ingredients that have never been clinically tested and, therefore, may be ineffective and even harmful. Many other products may contain some of the same ingredients as MigraineMD, but at suboptimal doses. In addition, none of the other products on the market are as complete as MigraineMD. MigraineMD delivers the best bang for your buck by including all known safe and effective ingredients at the right doses for maximal benefit.

Can natural supplements be harmful? Yes. Two such ingredients are commonly found in many other migraine supplements: butterbur and feverfew. Butterbur is a plant extract that may contain pyrrolizidine alkaloids which are toxic to the liver. Due to safety concerns, butterbur was removed from the market in Europe and is currently not recommended by the American Headache Society. In addition, feverfew is a plant extract that can stimulate uterine contractions thereby increasing the risk of preterm labor, and is not recommended during pregnancy by the American Headache Society. MigraineMD does not contain either of these ingredients.

Finally, MigraineMD has built-in sleep support. In addition to migraine prevention, magnesium and melatonin may also improve sleep quality.* Migraines can make it difficult to sleep, and poor sleep is a common migraine trigger leading to a vicious cycle of migraine pain. Therefore, MigraineMD works in more than one way to improve your migraines.

What is in MigraineMD?

It is recommended to take one to two capsules every night for at least 3 months for optimal results. Two capsules nightly is optimal, but taking one capsule may reduce side effects. Because magnesium and melatonin may promote sleep, MigraineMD should be taken close to bedtime.

Ingredients in Depth

Magnesium Citrate

Magnesium is involved in the production of ATP, which is the universal cellular energy source, and therefore promotes energy production. Furthermore, it regulates the excitability of neurons and the muscular tone of cerebral blood vessels, which are both negatively affected by migraines. Magnesium comes in many forms, but magnesium citrate specifically has the most evidence supporting its use in migraine prevention.

Vitamin B2

Vitamin B2, also known as riboflavin, is found in our mitochondria and is thought to improve migraines by maintaining energy stores in the brain.

Coenzyme Q10

Coenzyme Q10, also known as ubiquinone, is also found in our mitochondria and is required for producing energy in our cells. Coenzyme Q10 is thought to improve migraines by reducing the production of harmful reactive oxygen species and of CGRP, which is a pro-inflammatory molecule closely linked with migraines.

Melatonin

Melatonin is produced by our pineal gland in the brain. Its molecular structure is similar to indomethacin, a potent anti-inflammatory medication used to treat some types of headaches. In addition to its anti-inflammatory action, melatonin stabilizes neuronal excitability and potentiates GABA and opioid mechanisms for pain relief. Melatonin's primary role in our brain is to regulate our circadian rhythm, which is important for good sleep quality which is in turn critical for migraine prevention.

Vitamin D3

Vitamin D3 is important for neuronal development and reduces harmful reactive oxygen species. Vitamin D3 deficiency is very common because many people lack adequate sun exposure, which is our main source of vitamin D3. Vitamin D3 deficiency is associated with magnesium deficiency and more frequent migraines.

References

Click HERE to view the medical literature behind MigraineMD's evidence-based formula.