MigraineMD is 100% based on scientific evidence, but don’t take our word for it! Feel free to read the following peer-reviewed medical publications on which we’ve based our unique formula.

Migraine Epidemiology

Vos, T., et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2163-96. 

Steiner, T.J., et al. Migraine is first cause of disability in under 50s: will health politicians now take notice? The Journal of Headache and Pain. 2018;19:17. 

American Headache Society Recommendations

https://americanheadachesociety.org/wp-content/uploads/2022/12/Patient-Education-Kit-for-Migraine-Final-Supplements-11-27-22-Revision.pdf

Canadian Headache Society Guideline

Pringsheim, T., et al. Canadian Headache Society Guideline for Migraine Prophylaxis. Can J Neurol Sci. 2012; 39: Suppl. 2 - S1-S2.

Medrea I, Cooper P, Lagman-Bartolome AM, et al. Updated Canadian Headache Society Migraine Prevention Guideline with Systematic Review and Meta-analysis. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 2025;52(3):450-472. doi:10.1017/cjn.2024.285

American Migraine Foundation Spotlight On: Nutraceuticals

https://americanmigrainefoundation.org/resource-library/nutraceuticals/

Magnesium

Von Luckner, A., et al. Magnesium in Migraine Prophylaxis-Is There an Evidence-Based Rationale? A Systematic Review. Headache. 2018;58:199-209.

Mah, J., et al. Oral magnesium supplementation for insomnia in older adults: a Systematic Review & Meta-Analysis. BMC Complement Med Ther. 2021 Apr 17;21(1):125.

Summary: Magnesium citrate reduces the frequency of migraines by about 1-2 days/month. Magnesium may also help with sleep in older adults.

Riboflavin (Vitamin B2)

Thompson, D.F., et al. Prophylaxis of migraine headaches with riboflavin: A systematic review. Clin Pharm Ther. 2017;42:394–403.

Summary: Riboflavin reduces migraine frequency by about 2 days/month and reduces migraine severity.

Coenzyme Q10

Kaur, K., et al. The Efficacy of Herbal Supplements and Nutraceuticals for Prevention of Migraine: Can They Help?. Cureus. 2021;13(5): e14868.

Sazali, S., et al. Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine—a meta-analysis. BMJ Open. 2021; 11:e039358. 

Summary: CoQ10 reduces the frequency of migraines by about 2 days/month and reduces the duration of migraine attacks.

Vitamin D3

Gazerani, P., et al. A randomized, double-blinded, placebo-controlled, parallel trial of vitamin D3 supplementation in adult patients with migraine. Current Medical Research and Opinion. 2019;35:4, 715-723.

Song, T.J., et al. Effect of Vitamin D Deficiency on the Frequency of Headaches in Migraine. J Clin Neurol. 2018;14(3): 366–373.

Summary: Vitamin D3 reduces the frequency of migraines by about 2 days/month. In addition, migraines occur 1.2x more frequently in migraine patients with vitamin D deficiency compared to those without vitamin D deficiency.  

Melatonin

Peres, M.F.P., et al. Potential therapeutic use of melatonin in migraine and other headache disorders. Expert Opinion on Investigational Drugs. 2006; 15:4, 367-375.

Puliappadamb, H.M., et al. Efficacy and Safety of Melatonin as Prophylaxis for Migraine in Adults: A Meta-analysis. J Oral Facial Pain Headache. 2022;36(3-4):207–219.

Choi, K., et al. Efficacy of melatonin for chronic insomnia: Systematic reviews and meta-analyses. Sleep Med Rev. 2022 Dec:66:101692.

Summary: Melatonin reduces the frequency of migraines by about 1 day/month and reduces migraine duration and severity. Melatonin may also help with sleep in young adults.

Pediatric migraine supplements

Orr, S.L. The Evidence for the Role of Nutraceuticals in the Management of Pediatric Migraine: a Review. Current Pain and Headache Reports. (2018) 22(5):37.